Many patients are interested in the question of how effective Dexamethasone is in diabetes mellitus and whether this drug can be used to treat diseases of the adrenal glands if there is diabetes in the body.
In order to understand this issue in detail, it is necessary to determine what properties the medicine has, what constitutes it, as well as what contraindications to the use of the drug can be.
First of all, it should be noted that it is produced in the form of a solution for injection. For one milliliter of medication, there are four mg of active substance, in this case, it is dexamethasone sodium phosphate, and additional substances are present, such as:
- disodium edetate digibrat;
- sodium hydrogen phosphate dihydrate;
- water for injections.
If we talk about the first component, then it consists of 22.5 mg of the drug, but the second - 1 mg, the third is in an amount of 0.1 mg, well, almost one milliliter of water.
Externally, the drug resembles a clear liquid, sometimes the color may be close to a light yellow shade.
It should be noted that this drug is one of the most active glucocorticosteroids. Almost twenty-five, and sometimes thirty times. It does not promote the removal of positive potassium ions from the body, therefore it is considered much safer than other drugs of this pharmacological group.
Contraindications to the use of the drug
It is clear that, like any other remedy, this medicine also has some contraindications. For example, it cannot be used in the presence of a certain hypersensitivity to the components that are included in its composition.
The reason for the cancellation of treatment with this drug can be a different kind of infection. This usually occurs when effective antimicrobial drugs are not used during the course of the disease. The simultaneous use of this drug and live antiviral vaccines is also prohibited.
Although if we talk about all possible contraindications, the most important is precisely hypersensitivity. In all other cases, the use of the drug is completely safe. And judging from the performance indicators, this medicine is prescribed almost always, despite the possible contraindications.
As for the period of vaccination, it is better to refrain from treatment if the patient was vaccinated with BCG, namely if eight weeks had not passed from this date.
Caution should be taken when medication is used when the patient has HIV infection or AIDS.
The list of contraindications also includes diabetes. As well as other problems with the human endocrine system.
A complete list of possible contraindications is easy to find in the instructions for the drug.
I would like to dwell in more detail about the treatment of various diseases with this non-steroidal anti-inflammatory agent in diabetics. Above it has been said that the components that are part of the drug may increase the level of glucose in the blood.
This is due to the fact that after taking the medicine in the body, insulin synthesis is inhibited. Therefore, it is not recommended for use by a patient who suffers from type 2 diabetes.
But when it comes to patients with the first type of diabetes, treatment with this medicine is possible under the strict supervision of a doctor.
Special instructions for use
The first thing to note is the fact that treatment with this drug contributes to an increase in blood glucose levels. Therefore, patients with diabetes should use medication with extreme caution. Therapy is carried out under strict medical supervision with regular measurement of sugar level, if necessary, increasing the dose of sugar-lowering medication.
As mentioned above, Dexamethasone is not recommended for use in the presence of a certain susceptibility to various infections. This usually happens in situations where the patient has a low level of immunity.
For example, it can occur during the development of such a complex disease, like tuberculosis or AIDS. In both cases, it is important to use immunostimulatory drugs along with this drug, as well as those that have an antimicrobial effect.
It should be noted that after prolonged treatment with the above medication, namely for three weeks or more, it is important to cancel the medication gradually. Otherwise, there is a high probability that secondary adrenal insufficiency may develop.
If children are being treated, then it is important to observe the dynamics of their physiological development. Especially when it comes to long-term treatment for several months or even a year.
It is important during therapy to adjust your diet. It is better to choose those products that contain a large amount of potassium. And, of course, in general, the food should be healthy and rich in vitamins.
It is equally important to monitor the patient's state of health even after discontinuation of therapy. Somewhere in the year after the completion of the medication, a regular examination should be carried out to rule out the possibility of a relapse.
As for drug treatment during pregnancy, one should be very careful with this therapy. Only in the event that the expected result for the expectant mother far exceeds the possible risk to the fetus, should the treatment be started.
In the first trimester, it is better to refrain from taking this medication.
Instructions for use of the drug
Instructions for use of the drug contains a lot of information about exactly what diagnoses you need to use this medicine, as well as detailed dosage and side effects that the medicine can have.
If we talk about exactly what symptoms this remedy eliminates, and also under what diseases it should be used, then it becomes clear that the spectrum of action of the medication is quite wide.
Treatment with this tool should be carried out in the event that there is a need to remove high inflammation, which is present in the patient's body, as well as when it is necessary to prevent the development of edema, hyperemia and phagocytosis.
Of course, it should be noted that this drug has a more immunosuppressive property, so it is most often used to relieve symptoms, rather than eliminate the immediate causes of the underlying disease.
If you use the drug during various inflammatory processes, you will be able to reduce the likelihood of tissue response to this inflammation. It prevents the accumulation of leukocytes, and also has a number of other actions that suspend the inflammatory process in general.
Indications for use of the drug
Despite the fact that the drug restores the adrenal glands, thereby improving the production of the necessary hormones in the body, it is very rarely used in diabetes. This is due to the fact that this medicine helps to increase blood sugar levels. If, nevertheless, it is decided to use this medicine to treat patients with type 1 diabetes, then you need to increase the dose of sugar-lowering drugs and regularly monitor the level of glucose in the patient's blood.
The main indications for the use of the drug are:
- adrenal insufficiency;
- adrenal insufficiency (acute);
- adrenal insufficiency, which occurs as a result of abrupt cancellation of a certain group of drugs;
- primary or secondary failure of this organ.
In addition, it can also be prescribed if the patient has congenital hyperplasia of the cortex of this organ or subacute thyroiditis. The drug is effective for burns of any form, namely when any other vasoconstrictor drugs are ineffective. The diagnosis associated with cerebral edema, for example, various craniocerebral injuries, meningitis, encephalitis and other similar lesions, is no exception.
In some situations, this medicine can be used for severe bronchospasms, which occur during the development of bronchial asthma. It has been noted that it is also effective in case of varying severity of allergic reactions, mainly, of course, in severe forms of this disease, as a result of which it can be considered as one of the drugs that can be used when there are allergic manifestations in diabetes mellitus. Rheumatic diseases can also be a cause.
In general, this list is quite wide. But, of course, the use of medication is possible only after a full examination of the patient. It is impossible to begin therapy independently, the doctor should carry out prescription of a medicine.
Reviews on the use of the drug
There are quite a few reviews on the Internet that make it possible to understand in which situations it is best to refuse to use this medication, and in which it is most effective.
For example, some patients claim that after long-term medication they observed such side effects as menstruation disorders, the development of secondary adrenal insufficiency. Particular care should be taken when treating patients who have diabetes. Since the components of the drug significantly reduce glucose tolerance. If you use the medication for a very long time, growth may be inhibited in children.
Possible side effects from the work of the cardiovascular system.
Reviews of patients who used this medicine during the treatment of their diseases suggest that it is very effective in various septic arthritis, as well as when it is administered to unstable joints orally.
However, the same reviews indicate that the drug can harm the patient’s health if he has various diseases of the gastrointestinal tract, as well as fungal infection, herpes, chicken pox or measles.
Of course, as in any other case, you can also find both positive and negative reviews. But, despite the large number of side effects, the effectiveness of this medicine is above all the negative consequences. The main thing is to carry out the treatment under strict medical supervision.
The cost of the drug and its analogues
If we talk about the cost of this medicine, it is quite affordable. Of course, it all depends on the specific manufacturer and form of release, but in general the price per package does not exceed 100 rubles.
True, there are exceptions, for example, Dexamethasone Vial from the C & S company costs 254 rubles. In this price range is the drug, which offers the manufacturer from India and Slovenia, in this case, the cost reaches 215 rubles, but the package will have 25 ampoules, each of which contains 1 ml of therapeutic substance with a concentration of 4 mg.
In general, it should be noted that all drugs from different manufacturers, which are sold in a package that contains 25 ampoules of one ml each, are in the range from 212 to 225 rubles.
If we talk about a medicine that is sold in the form of eye drops, then its cost most often does not exceed 40 rubles. But here we are talking about a solution with a concentration of 0.1%. Of course, its price may be higher, it all depends on the volume of the container.
It should be noted that before embarking on the use of a therapeutic agent, it is better to consult with your doctor in advance and to clarify the form of release of the desired drug and its concentration, and only then acquire the medication. The video in this article will tell about the drug.