Mettopogamma 850 is an effective hypoglycemic agent. Used in the treatment of type 2 diabetes. It has a persistent hypoglycemic effect. Promotes weight reduction and retention.
International non-proprietary name
Mettopogamma 850 is an effective hypoglycemic agent. Used in the treatment of type 2 diabetes.
ATH code: АВАВА02
Forms of release and composition
Round tablets which are film coated and practically have no specific tablet smell. The main substance is metformin hydrochloride 850 mg. Additional components: carboxymethyl starch sodium, silica, magnesium stearate, corn starch, povidone, hypromellose, macrogol 6000, titanium dioxide, talc, propylene glycol.
The tablets are packaged in blisters, 10 pieces. A carton pack contains 3, 6 or 12 blisters and a medication guide. There are also packs with 20 tablets in a blister. In a carton pack 6 such blisters are packed.
This drug belongs to the group of biguanides. It is a hypoglycemic drug that is intended for oral administration.
The active substance contributes to the inhibition of gluconeogenesis, which occurs in the liver cells. Glucose absorption from the digestive tract organs is reduced, and its utilization in peripheral tissues is only enhanced. Insulin sensitivity increases.
Metphogamma belongs to the biguanide group. It is a hypoglycemic drug that is intended for oral administration.
As a result of the use of tablets, the level of triglycerides and lipoproteins decreases. At the same time, body weight becomes less and remains at a normal level for a long time. The drug inhibits the action of plasminogen activator inhibitor, which contributes to a pronounced fibrinolytic effect of the drug.
Metformin is absorbed from the digestive tract in a short time. Bioavailability and ability to bind to blood proteins is low. The greatest number of drugs in the blood plasma is observed after a couple of hours. The drug tends to accumulate in the muscle tissue, liver, salivary glands and kidneys. Excretion is carried out using renal filtration, unchanged. The half-life is 3 hours.
Indications for use
Type 2 diabetes, proceeding without the risk of ketoacidosis, and obesity (with the ineffectiveness of diets).
There are a number of contraindications when the drug can not be used:
- hypersensitivity to the components;
- diabetic ketoacidosis;
- diabetic precoma;
- renal impairment;
- heart and respiratory failure;
- lactic acidosis;
- breastfeeding period;
- surgical interventions;
- abnormal liver function;
- acute alcohol poisoning;
- radiography with contrast 2 days before or after the start of therapy;
- adherence to a low-calorie diet.
Not recommended for people over 60 who are engaged in hard work, because they may cause lactic acidosis.
How to take Mettophamma 850?
Drink pills while eating. To swallow completely, without breaking and not chewing, to drink boiled water. The course of treatment is long. Due to the increased risk of lactic acidosis (in the presence of metabolic disorders), the dose is recommended to be reduced to the minimum.
Dose set individually, taking into account the indicator of blood sugar. Start with 1-2 tablets per day. If this treatment does not give the desired therapeutic effect, the dosage can be gradually increased. Maintenance dose - 2-3 tablets per day, but not more than 4 pieces.
Side Effects of Methopogamy 850
With prolonged admission or violation of the dosage, a number of adverse reactions may occur that require changing the dose or replacing the medication.
Digestive disorders: diarrhea, nausea, vomiting, pain in the abdomen, taste of metal in the mouth, flatulence. These symptoms will disappear over the course of several days.
If you take Medfogamma 850 for a long time, or if the dosage is disturbed, a number of adverse reactions may occur, requiring a dose change or replacement of the medication.
Seldom: megaloblastic anemia.
central nervous system
In severe hypoglycemia or lactic acidosis, the appearance of convulsive syndrome, tremor, hypoxia may occur.
Since the cardiovascular system
There is a risk of developing cardiac and vascular disorders in the form of tachycardia, anemia, increased blood pressure and other symptoms of hypoglycemia.
On the part of the endocrine system
Lactic acidosis, hypovitaminosis and impaired absorption of vitamin B12.
In some cases, allergic reactions in the form of a skin rash may occur.
Pregnant women with type 2 diabetes should not be treated with metformin.
Use during pregnancy and lactation
Pregnant women with type 2 diabetes should not be treated with metformin. To maintain normal glucose levels, insulin replacement therapy is performed. This will reduce the risks to the fetus.
The active substance quickly penetrates into breast milk, which can adversely affect the health of the child. Therefore, for the period of drug therapy is better to refuse breastfeeding.
During treatment, you need to monitor the work of the kidneys and blood glucose indicators. When symptoms of myalgia occur, determine the amount of lactate in the plasma.
Use in old age
It requires caution, because in people over 65, there is a high risk of hypoglycemia, lactic acidosis, impaired renal function, liver, and heart failure. Therefore, the dose should be adjusted for each patient individually, taking into account the onset of complications of diabetes.
The drug Metfohamma 850 is not recommended for children under 10 years of age.
Appointment to children
It is not recommended to take this drug to children under 10 years old. In adolescence, prescribed the minimum effective dosage of medication. But it is better to carry out treatment with standard insulin.
Influence on ability to operate mechanisms
When using tablets in conjunction with other hypoglycemic agents, symptoms of hypoglycemia may occur, which indirectly affect the speed of psychomotor reactions and concentration of attention. Therefore, for the period of treatment it is better to refrain from self-driving.
Use in violation of kidney function
Prescription medication will depend on creatinine clearance. If it is too high, then we can talk about severe renal failure. In this case, the use of metformin is prohibited.
Use in violation of the liver
Tablets can be used only in the case of lung liver dysfunction. In case of severe hepatic insufficiency, medication is strictly prohibited.
In case of severe liver failure, taking the drug Metphogamma is strictly prohibited.
Overdose of Mettopogamma 850
When used with Methopogamma at a dosage of 85 g, no symptoms of overdose were observed. With increasing doses of medication may develop hypoglycemia and lactic acidosis. At the same time adverse reactions are aggravated. Subsequently, the patient may have a fever, pain in the abdomen and joints, increased breathing, loss of consciousness and coma.
When these signs appear, the drug is immediately stopped, the patient is hospitalized in the hospital. The drug is removed from the body by hemodialysis.
Interaction with other drugs
When used simultaneously with many sulfonylurea derivatives, insulin, MAO and ACE inhibitors, Cyclophosphamide, nonsteroidal anti-inflammatory drugs, clofibrate derivatives, tetracyclines and individual beta-adrenoblockers, the hypoglycemic effect of metformin is enhanced.
Glucocorticosteroids, sympathomimetics, epinephrine, glucagon, many OK, thyroid hormones, diuretics, and nicotinic acid derivatives lead to a decrease in the hypoglycemic effect of the drug.
Cimetidine slows down the absorption of metformin, which often leads to the development of lactic acidosis. The active substance reduces the effect of the use of anticoagulants, mainly coumarin derivatives.
Nifedipine increases absorption, but slows down the elimination of the active substance from the body. Digoxin, morphine, quinine, Ranitidine and Vancomycin, which are secreted mainly in the tubules, with prolonged therapy increases the time of elimination of the drug.
Compatibility with alcohol
Taking pills can not be combined with alcoholic beverages, because co-administration with ethanol contributes to the development of lactic acidosis.
Taking tablets Metfogamma can not be combined with alcoholic beverages, because co-administration with ethanol contributes to the development of lactic acidosis.
There are substitutes that have similarities in composition and action:
- Dianormet 1000,500,850;
- Metformin Hexal;
- Metformin Zentiva;
- Metformin Sandoz;
- Metformin Teva;
- Emnorm Er.
Pharmacy vacation terms
Can I buy without a prescription?
The estimated price in Russia is about 300 rubles. per pack.
Drug storage conditions
Dark and dry place, temperature conditions not higher than + 25 ° C.
5 years from the date of issue indicated on the original packaging. Do not take after this deadline.
Production company: Dragenopharm Apothecary Puschl GmbH, Germany.
Minailov A.S., 36 years old, endocrinologist, Yekaterinburg: “I often give Metfohamam 850 diabetics with overweight. He keeps sugar well. It is convenient to take, because the daily dose is taken 1 time. The price is affordable, people afford. "
Pavlova MA, 48 years old, endocrinologist, Yaroslavl: “I try to prescribe metophammu cautiously. There are drawbacks to the drug, it is not always well tolerated and sometimes causes undesirable reactions. If a chronic disease or drug I cancel. "
Roman, 46 years old, Voronezh: “A few years ago I was diagnosed with diabetes mellitus. Metathogamm 850 was prescribed in pills after I tried a couple of other drugs, and they did not keep sugar. I am satisfied with the result.”
Oleg, 49 years old, Tver: "I have been taking the drug for half a year. The analyzes are normal. But still, I constantly visit an endocrinologist, because even the" banal "flu can cause serious complications while taking this medicine."
Reviews losing weight
Katerina, 34, Moscow: “How much I couldn’t diets, I couldn’t lose weight enough, and with a lot of weight it’s not far from diabetes. I had a lot of kidney problems. I stopped taking the drug and went on a diet again. I came to the conclusion that diabetics need this medicine to keep sugar, and not healthy people to lose weight. "
Anna, 31, Yaroslavl: “After giving birth, I could not lose weight. I didn’t do anything. The doctor advised me to drink this drug. I drank 2 tablets a day. For 1.5 months I lost 6 kg. No adverse reactions I did not arise. "